Compare GLP-1 Medications

See how the most common GLP-1 medications compare across dosing, pricing, FDA status, and side effects.

	semaglutide	semaglutide (oral)	tirzepatide	compounded semaglutide	compounded tirzepatide	orforglipron	retatrutide
Brand Names	Ozempic, Wegovy	Rybelsus, Wegovy Oral	Mounjaro, Zepbound	N/A	N/A	Foundayo	N/A
Manufacturer	Novo Nordisk	Novo Nordisk	Eli Lilly	Various 503A/503B pharmacies	Various 503A/503B pharmacies	Eli Lilly	Eli Lilly
Route	injection	oral	injection	injection	injection	oral	subcutaneous injection
FDA Approved
Dose Range	0.25mg - 2.4mg weekly	3mg - 25mg daily	2.5mg - 15mg weekly	0.25mg - 2.5mg weekly	2.5mg - 15mg weekly	3mg - 36mg daily	1mg - 12mg weekly (Phase 3 dose range)
Monthly Cost (Branded)	$1,300	$1,000	$1,100	N/A	N/A	$649	N/A
Monthly Cost (Savings)	$499	$149	$299	N/A	N/A	$149	N/A
Side Effects	Nausea, Vomiting, Diarrhea, Constipation, Abdominal pain	Nausea, Vomiting, Diarrhea, Constipation	Nausea, Vomiting, Diarrhea, Decreased appetite, Constipation	Nausea, Vomiting, Diarrhea, Constipation	Nausea, Vomiting, Diarrhea, Decreased appetite	Nausea, Vomiting, Diarrhea, Constipation, Decreased appetite	Nausea, Diarrhea, Vomiting, Constipation, Decreased appetite, Transient heart rate increase

semaglutide

Ozempic, Wegovy

ManufacturerNovo Nordisk

Routeinjection

FDA Approved

Dose Range0.25mg - 2.4mg weekly

Cost (Branded)$1,300

Cost (Savings)$499

Side EffectsNausea, Vomiting, Diarrhea, Constipation, Abdominal pain

semaglutide (oral)

Rybelsus, Wegovy Oral

ManufacturerNovo Nordisk

Routeoral

FDA Approved

Dose Range3mg - 25mg daily

Cost (Branded)$1,000

Cost (Savings)$149

Side EffectsNausea, Vomiting, Diarrhea, Constipation

tirzepatide

Mounjaro, Zepbound

ManufacturerEli Lilly

Routeinjection

FDA Approved

Dose Range2.5mg - 15mg weekly

Cost (Branded)$1,100

Cost (Savings)$299

Side EffectsNausea, Vomiting, Diarrhea, Decreased appetite, Constipation

compounded semaglutide

ManufacturerVarious 503A/503B pharmacies

Routeinjection

FDA Approved

Dose Range0.25mg - 2.5mg weekly

Cost (Branded)N/A

Cost (Savings)N/A

Side EffectsNausea, Vomiting, Diarrhea, Constipation

compounded tirzepatide

ManufacturerVarious 503A/503B pharmacies

Routeinjection

FDA Approved

Dose Range2.5mg - 15mg weekly

Cost (Branded)N/A

Cost (Savings)N/A

Side EffectsNausea, Vomiting, Diarrhea, Decreased appetite

orforglipron

Foundayo

ManufacturerEli Lilly

Routeoral

FDA Approved

Dose Range3mg - 36mg daily

Cost (Branded)$649

Cost (Savings)$149

Side EffectsNausea, Vomiting, Diarrhea, Constipation, Decreased appetite

retatrutide

ManufacturerEli Lilly

Routesubcutaneous injection

FDA Approved

Dose Range1mg - 12mg weekly (Phase 3 dose range)

Cost (Branded)N/A

Cost (Savings)N/A

Side EffectsNausea, Diarrhea, Vomiting, Constipation, Decreased appetite, Transient heart rate increase

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